Active Immunity
Released 30 October 2026 · PC · Action, Indie
A twin-stick bullet-hell roguelite fought inside the human body. Pilot an immune cell through escalating waves of pathogens, dodge dense bullet patterns, and stack upgrades into synergies that rewrite your build. Choose how each outbreak mutates, then push a run into endless.
Story
Something has slipped past the skin. You are what the body sends back. Active Immunity is a twin-stick bullet-hell roguelite fought inside the human body. Pick an immune cell, drop into infected tissue, and hold the line through 25 escalating waves of bacteria, viruses, fungi, parasites and worse. Weave through dense bullet patterns, stack upgrades into a build that feels unfair, and when the campaign is cleared, find out how long you last in endless. Every cell has its own fire pattern, stats and special ability. Start as the Natural Killer Cell, and take each cell to wave 10 to unlock the next. Natural Killer Cell - a glass cannon that answers a crowd with a 20-bullet radial burst. T Helper Cell - support fire and a cytokine nova that clears the space around you. B Cell - antibody spreads and an opsonizing barrage: marked pathogens take 35% more damage. Macrophage - a tanky brawler that dashes straight through the swarm. Neutrophil - triple-shot fire and an extracellular trap that destroys enemy bullets. Dendritic Cell - a tactical debuffer whose antigen presentation boosts your damage 1.75x. Every level-up is a choice. Draw from 54 upgrades across five rarities, from...
Gameplay
Something has slipped past the skin. You are what the body sends back. Active Immunity is a twin-stick bullet-hell roguelite fought inside the human body. Pick an immune cell, drop into infected tissue, and hold the line through 25 escalating waves of bacteria, viruses, fungi, parasites and worse. Weave through dense bullet patterns, stack upgrades into a build that feels unfair, and when the campaign is cleared, find out how long you last in endless. Every cell has its own fire pattern, stats and special ability. Start as the Natural Killer Cell, and take each cell to wave 10 to unlock the next. Natural Killer Cell - a glass cannon that answers a crowd with a 20-bullet radial burst. T Helper Cell - support fire and a cytokine nova that clears the space around you. B Cell - antibody spreads and an opsonizing barrage: marked pathogens take 35% more damage. Macrophage - a tanky brawler that dashes straight through the swarm. Neutrophil - triple-shot fire and an extracellular trap that destroys enemy bullets. Dendritic Cell - a tactical debuffer whose antigen presentation boosts your damage 1.75x. Every level-up is a choice. Draw from 54 upgrades across five rarities, from Common to Legendary, and max one out to unlock its evolution - 11 in all. Put the right pieces together and one of 23 synergies kicks in, turning a decent build into a screen-clearing one. Eight...
Features
- Single-player
- Multi-player
- Co-op
- Online Co-op
- Steam Achievements
- Full controller support
- Steam Workshop
- Camera Comfort
Release details
Active Immunity is a Action and Indie game by Dylpickle Studios. Active Immunity came out on Friday, 30 October 2026 on PC. This date comes from Steam and was last checked on 29 October 2026.
Frequently asked questions
When did Active Immunity come out?
Active Immunity came out on 30 October 2026.
Which platforms is Active Immunity on?
Active Immunity is on PC.
Who makes Active Immunity?
Active Immunity is developed by Dylpickle Studios.
What kind of game is Active Immunity?
Active Immunity is a game of these genres: Action and Indie.